Stem Cell Regulation - 633 Words

Skin with its hair follicle is an excellent system to study molecular mechanism of stem cell regulation. Due to constant need of tissue regeneration, it has abundant number of stem cells. Hair follicle consist of a permanent portion- sebaceous gland and below it is a bulge area, which houses- Hair follicle epidermal stem cells(HFSCs). Bulge also provides niche for melanocyte stem cells interspersed between HFSCs. Behavior of the two stem cells is well coordinated. Differentiating melanocytes transfer pigment to terminally differentiated hair follicles (Nishimura et al., 2002; Tanimura et al., 2011; Rabbani et al., 2011).Hair follicle undergoes cyclical bouts of 3 phases-anagen (phase of active growth), catagen (destruction phase) and telogen (rest phase) (Hardy, 1992). HFSCs give rise to daughter stem cells which are retained in the bulge area and others form, either epidermal progenitors which migrate upwards during tissue repair or it forms hair-matrix progenitors which migrate bel ow to form hair shaft (Niemann Watt 2002; Oshima et al., 2001; Taylor et al. 2000). In early 1990s, HFSCs were located in the bulge region by label retention studies (Cotsarelis et al., 1990; Morris and Potten, 1994). Later in 2001, presence of HFSCs in bulge area was confirmed by transplantation experiments. When lac-z labeled bulge region from adult mice was transplanted into hairless mice, lac-z labeled cells formed morphologically distinct hair follicle (Oshima et., 2001). Lineage tracingShow MoreRelatedSCI Case Study1591 Words   |  7 Pagesusing stem cell therapy, so I’ll try and provide you with as much information as I know. Currently in Australia and around the world, there are no proven cures for SCI using stem cells, this is according to the Australia and New Zealand Spinal Cord Injury Network (Stem Cell Interventions for Spinal Cord Injury, 2009) and icord.org (Steeves et al., 2012), both leading organisations in SCI treatment. There are however, clinical trials and research going on around the world that use stem cells to treatRead MoreStem Cel ls Essay1699 Words   |  7 Pagescontroversial research in stem cells. This technology offers hope to millions who are victims of a multitude of diseases and disorders. It can be used to regrow limbs, create organs, attack genetic diseases, treat malfunctioning bladders, etc. However, this same technology is also one of the most controversial debates in science today. If you type â€Å"stem cells research† into your Google search bar, you will most likely find not only advances in this field or a basic overview of stem cells, but articles onRead MoreStem Cell Essay939 Words   |  4 PagesInduced Pluripotent Stem Cells and their use in Cardiac Regeneration Introduction Myocardial infarction (MI) is the leading causes of mortality and morbidity in the world. Ischemic heart disease, where the oxygen supply to the myocardium is restricted, is a common cause of an MI. Myocardial injury results in loss of cardiomyocytes (cardiac muscle cells) due to apoptosis, and the development of necrotic myocardium, eventually leading to heart failure. The formation of the necrotic myocardium causesRead MoreStem Cells And The Future Essay1441 Words   |  6 PagesENC 1101-20M 1 December 2016 Stem Cells and the Future What exactly are stem cells? How can the use of these cells benefit us and how exactly are they acquired? Believe it or not stem cells have been in play when it comes to medicine since the 1950’s in France (Steenblock 1). This topic is very controversial and I surmise that it is strongly due to the lack of knowledge when it comes to stem cells and their importance. I, myself, am very intrigued by stem cells and my goal is to define whatRead MoreA Research Study On Stem Cell1225 Words   |  5 Pages My research about stem cells, I will be talking about what a stem cell is. Why are stem cells important from a medical perspective? How are stem cells being used today? Where do scientists get stem cells? Why is so much controversy over the stem cells? How does a zygote develop into a baby? Why a zygote is considered a stem cell? A stem cell is an immature cell that can help reproduce different types of cells throughout the body. There are three types of stem cells that I will be focusing on : adultRead More Stem Cell Research Essay1316 Words   |  6 PagesStem Cell Research What is a Stem Cell? Stems cells are immature cells found in embryos that can develop into any kind of specialized cells. They can form virtually any cell of the human body. These types of stem cells are known as pluripotent cells. Multipotent cells are stem cells that are more mature; they can be found in adults and children. Multipotent cells are not as flexible as pluripotent cells, as they have already developed into more specialized human cells. Benefits of StemRead MoreResearch On Stem Cell Research1582 Words   |  7 Pagesand dilemmas is stem cell research. The conflicts are specific types of stem cells are unethical and not morally right to research on, but not all stem cells are this way. Stem cell research is the study of different types of stem cells and their possible clinical uses. Stem cells can be developed to act as treatments for different types of illnesses and diseases, but currently no push for funding the advancement of research on stem cells are being taken. Even though some stem cells create conflictsRead MoreStem Cell Research And The Medical Field Essay1736 Words   |  7 PagesStem cells have become one of the largest research fields in the Department of Regenerative Medicine. They are often referred to as the â€Å"building blocks of nature† due to their ability to transform into any type of cell in the human body. It has led to the controversy of the possible chance that stem cells can regene rate organs, and cure life threatening diseases. This topic has been publicly discussed among scientists and healthcare professionals. There are different types of stem cells, such asRead MoreThe Controversy Over Stem Cell Research1169 Words   |  5 Pagesyears, stem cell research has become a prominent way of treating: heart disease, cancer, HIV/AIDS, spinal problems, and much more ; moreover, in recent years as Stem cell research became more popular, it has sparked controversy over the religion aspect of stem cell research. Stem cell research begins with culturing an embryonic cell and then injecting the stem cell into the area of concern(Robertson). Pluripotent stem cells are gathered and used to treat the areas, pluripotent stem cells are thoseRead MoreThe Controversy Of Embryonic Stem Cells1034 Words   |  5 PagesFor decades, researchers’ use of stem cells has caused a controversy and the consideration of the ethics of research involving the development, usage, and destruction of human embryos. Most commonly, this controversy focuses on embryonic stem cells. Not all stem cell research involves the creation, usage and destruction of human embryos. For example, adult stem cells, amniotic stem cells and induced pluripotent stem cells do not involve creating, using or destroying human embryos and thus are